Investigation of receptor ligand interaction on the cell surface

One of the most important fields in medicine, pharmacy and biotechnology is the study of interacting molecules, which allows us to use this knowledge to develop more effective drugs for the treatment of diseases. When developing preparations for treating diseases, it is important to find out the specificities of interactions between molecules, how many surface receptors must be activated for signal transduction in cells, the strength or duration of the interaction, and so on. Artificial membrane analogues or other derivatives that mimic membrane surfaces are commonly used to study protein-ligand interactions (Sezgin and Schwille, 2012). However, the interaction between biomolecules is strongly influenced by the physiological environment and membrane mobility of the receptor. There is a great need for models to study the interaction of biomolecules on the cell surface under realistic conditions.
For more information, please contact the theme supervisor A. Stirkė.