The ultimate goal of this project will be to develop a super-resolution and ultra-fast full-field optical coherent microscopy (FF-OCM) system that would help to improve diagnosis of the human eye diseases. FF-OCM is based on interferometric signal detection that can effectively image non-labelled structures deep inside biomedical samples. Currently, the fastest FF-OCM systems rely on illuminating sample with a swept laser source and detecting signal with an ultra-fast camera (used to capture ultra-slow-motion videos). Although FF-OCM has been successfully used for a range of biomedical applications, however, the speed and resolution remain limited, especially in in vivo imaging situations. During the PhD, various sample illumination and signal detection approaches will be investigated to improve the spatial resolution beyond the diffraction limit. For example, photon reassignment principles will be employed that correct the spatial position of detected photons to their respective ‘super-resolved’ locations by the help of digital-micromirror devices (DMD) and spatial light modulators (SLM).
For more information, please contact the theme supervisor E.Auksorius.